Candidate of Medical Sciences, Siberian State Medical University

Ludmila Smaglii

Research supervisor

University

Siberian State Medical University

Level of English proficiency

Upper-Intermediate (B2)

Educational program and field of the educational program for which the applicant will be accepted
1.5 Biological sciences (field of study)
1.5.2 Biophysics (major) 
List of research projects of the potential supervisor (participation/leadership)
  1. Grant from the Russian Science Foundation No. 23-25-00259 "Multichannel electrical stimulation of the otolith membrane and semicircular canals of the vestibular organ" (participation), 2022-2024
  2. Grant from the Russian Foundation for Basic Research No. 19-415-703015 "Investigation of ionic mechanisms of vascular tone regulation in a model of metabolic syndrome" (participation), 2019-2020
  3. Grant from the Russian Foundation for Basic Research No. 18-44-703008 "Role of Cl–-transport in the ATP-dependent regulation of smooth muscle contractility in pulmonary circulation vessels", (leadership role), 2018-2019
  4. Grant from the Russian Foundation for Basic Research No. 18-44-700009 "Investigation of volume-dependent mechanisms regulating the contractile activity of smooth muscle cells in pulmonary circulation vessels", (participation), 2018-2020
  5. Grant from the Russian Foundation for Basic Research No. 18-315-00296 "Investigation of volume-dependent mechanisms regulating the contractile activity of smooth muscle cells by gasotransmitters", (participation), 2018-2019
  6. Grant from the Russian Foundation for Basic Research No. 18-015-00395 "Identification of intracellular targets and components of signaling systems mediating gasotransmitter effects on blood cells", (participation), 2018-2019
  7. Grant from the Russian Foundation for Basic Research No. 16-34-00419 "Role of gasotransmitters in regulating the myogenic tone of vascular smooth muscle in hypoxia", (participation), 2016-2017
  8. Grant from the Russian Foundation for Basic Research No. 16-34-00262 "Investigation of the role of gasotransmitters in the purinergic regulation of smooth muscle cell contractility", (leadership role), 2016-2017 
List of the topics offered for the prospective scientific research
  1. JNK-mediated regulation of pulmonary artery tone
  2. Reactive oxygen species in a model of immobilization stress in rats
  3. Gasotransmitters in a model of immobilization stress in rats
  4. Purinergic regulation of cerebral arteries
  5. Role of gasotransmitters in purinergic regulation of muscular arteries
  6. Effects of low-dose ionizing radiation on the functional activity of vascular cells
  7. Molecular mechanisms of cell adaptation to low-dose ionizing radiation 
Supervisor’s research interests
Intracellular signaling systems, cell electrophysiology, ion channels, regulation of vascular tone.
Supervisor’s specific requirements:
  • A degree in biology, biophysics, human and animal physiology.
  • Excellent English language skills
  • Experience of participation in research projects
  • Basic knowledge of statistical analysis in medical and biological research 
Supervisor’s main publications
The total number of publications in journals indexed by Web of Science, Scopus, RSCI over the past 5 years is 40

  1. V.P. Demkin, S.V. Melnichuk, M.V. Svetlik, M.D. Akinina, T.V. Rudenko, V.M. Alifirova, O.V. Grebenuk, L.V. Smaglii, O.V. Demkin. Propagation of electrical signals through the tissue of the vestibular organ by stimulating otolith membranes // Russian Physics Journal. 2024. Vol. 67, No. 9. P. 20‒30. DOI: 10.17223/00213411/67/9/2
  2. Smaglii L.V., Gusakova V.S., Gusakova S.V., Pshemyskiy M.A., Koshuba S.O., Golovanov E.A. Isosmotic contraction of rat aortic smooth muscle cells upon activation of purinergic receptors: the role of chlorine transport // Journal of Evolutionary Biochemistry and Physiology. 2024. Vol. 60. No. 3. P. 1187-1197. DOI: 10.1134/s0022093024030256
  3. V.P. Demkin, S.V. Melnichuk, M.V. Svetlik, L.V. Smaglii, T.V. Rudenko, V.A. Zaitsev, V.M. Alifirova, O.V. Grebenuk. Physical and mathematical model of otolith organs and numerical simulation of the dynamics of animal’s otolith membrane layers under the action of a mechanical stimulus // Russian Physics Journal. 2023. Vol. 66, No. 9. P. 17‒28. DOI: 10.17223/00213411/66/9/2
  4. Birulina Y.G., Ivanov V.V., Buyko E.E., Gabitova I.O., Kovalev I.V., Nosarev A.V., Smagliy L.V., Gusakova S.V. Role of H2S in regulation of vascular tone in metabolic disorders // Bulletin of Experimental Biology and Medicine. 2021. Vol. 171. No. 4. P. 436-440.
  5. Smaglii L.V., Gusakova V.S., Gorianova A.M., Golovanov E.A., Chibisov E.E., Birulina J.G., Gusakova S.V. Role of ATP and Cl-transporters in regulation of contractile activity of pulmonary artery smooth muscles in hyposmotic conditions // Arterial’naya Gipertenziya (Arterial Hypertension). 2020. Vol. 26. No. 5. P. 573-580. DOI 10.18705/1607-419X-2020-26-5-573-580. 

Results of intellectual activity
  1. The number of study guides - 4.
  2. Registered databases:Database / Database of physiological and biochemical parameters of animals when modeling metabolic syndrome / RU 2020621414. August 12, 2020 Database / Database of research findings on the impact of hydrogen sulfide and carbon monoxide donors on human erythrocytes / RU 2019621170, July 2, 2019
  3. Registered patents: Patent / Method for modeling diet-induced metabolic syndrome / RU 2740007 C1, December 30, 2020
Certificate of computer program registration / OTOLDEFORM-1.0. Numerical calculation of the otolith membrane deformation under the influence of a periodic mechanical stimulus / RU 2024612508, February 1, 2024.