Doc.Med.Sci., professor, Siberian State Medical University

Olga Vaizova

Research supervisor

University

Siberian State Medical University

Level of English proficiency

Upper-Intermediate (B2)

Educational program and field of the educational program for which the applicant will be accepted
3.3 Medical and Life Sciences (educational program)
3.3.6 Pharmacology, clinical pharmacology (field of the educational program) 
List of research projects of the potential supervisor (participation/leadership)
  1. Grant No. 14.601.21.0015 of the Ministry of Education and Science within the framework of the federal target program “Research and development in priority areas of the Russian science and technology sector for 2014-2020” on the topic “Forecasting of the priority implementation of scientific and technological development defined in paragraph 20v “Transition to the personalized medicine, high-technology healthcare and health protection technologies including through rational use of medical products (primarily antibacterial)” of the Strategy for Scientific and Technological Development of the Russian Federation, 2017-2018, participation; 
  2. Grant No. 14.N08.11.0136 of the Ministry of Education and Science within the framework of the federal target program “Development of pharmaceutical and medical industry of the Russian Federation until 2020 and beyond” on the topic “Preclinical studies of medical products based on a neuraminidase inhibitor for the influenza treatment”, 2017-2019, participation 
List of the topics offered for the prospective scientific research
  1. Search for potential antineoplastic compounds among aminonaphthoquinone derivatives (in silico assessment and in vitro analysis)
  2. Search for potential inhibitors of integrin family proteins with antineoplastic activities
  3. Role of the alpha v beta 1 integrins in regeneration and fibrotic process
  4. Search for potential inhibitors of alpha v beta 1 integrin to prevent fibrosis (in silico assessment and in vitro analysis)
  5.  Development of the inhibitors of alpha 6 beta 4 integrins with antineoplastic action (in silico assessment andin vitro analysis)
  6. The possibility of prevention of neoplastic transformation by inhibiting isolated intracellular proteins 
Supervisor’s research interests
Molecular pharmacology, docking, search for potential bioactive compounds (small molecules)
Research highlights
Working with cultures of human tumor cells
Supervisor’s specific requirements:
  • Knowledge of pharmacology (required), advanced PC-user (would be an asset), knowledge of docking methods (Rosetta, Rosi, etc. would be an asset), knowledge of cultural methods (would be an asset), knowledge of spectrophotometry/ spectrofluorimetry methods (would be an asset)
Supervisor’s main publications
The total number of publications over the last 5 years is 11 including:

  1. Skurikhin E.G., Pershina O.V., Pakhomova A.V., Pan E.S., Krupin V.A., Ermakova N.N., Vaizova O.E., Pozdeeva A.S., Zhukova M.A., Skurikhina V.E., Grimm W.D., Dygai A.M. Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease // International Journal of Molecular Sciences. – 2019. – V. 20. – № 5. – pii: E1105. https://doi.org/10.3390/ijms20051105
  2. Gender Differences in the Pharmacological Effects of Pegylated Glucagon-Like Peptide-1 in the Combination of Metabolic Disorders and Emphysema of the Lungs Should Be Sought in Endothelial Progenitor Cells and Angiogenesis Precursors // Int.J.Mol.Sci. 2019; 20(21): 5414; https://doi.org/10.3390/ijms20215414
  3. Pakhomova A.V., Pershina O.V., Ermakova N.N., Krupin V.A., Pan E.S., Putrova O.D., Khmelevskaya E.S., Vaizova O.E., Pozdeeva A.S., Dygai A.M., Skurikhin E.G. Pericytes and Smooth Muscle Cells Circulating in the Blood as Markers of Impaired Angiogenesis during Combined Metabolic Impairments and Lung Emphysema // Bulletin of Experimental Biology and Medicine. – 2020. –V. 168. –№ 3. –P. 334-340.
  4. Pakhomova A., Nebolsin V.E., Pershina O., Krupin V.,Sandrikina L., Pan E., Ermakova N., Vaizova O., Widera D., Wolf-Dieter Grimm, Kravtsov V., Afanasiev S., Morozov S., Kubatiev A., Dygai A., Skurikhin E. Antidiabetic effects of bisamide derivative of dicarboxylic acid in metabolic disorders // International Journal of Molecular Sciences. – 2020. – Vol. 21. – № 3. – P. 991. doi: 10.3390/ijms21030991. PMID: 32028560; PMCID: PMC7037053.
  5. Anfinogenova ND, Stepanov VA, Chernyavsky AM, Karpov RS, Efimova EV, Novikova OM, Trubacheva IA, Falkovskaya AY, Maksimova AS, Ryumshina NI, et al. Clinical Significance and Patterns of Potential Drug–Drug Interactions in Cardiovascular Patients: Focus on Low-Dose Aspirin and Angiotensin-Converting Enzyme Inhibitors // Journal of Clinical Medicine. – 2024. – 13(15):4289. https://doi.org/10.3390/jcm13154289 

Results of intellectual activity
  1. Under the supervision of the research supervisor 3 PhD theses were defended
  2. 7 patents of invention were received
  3. 10 published training manuals