Siberian State Medical University

Upper-Intermediate (B2)

1. "Development of a structure-property model for the creation of new iron-containing drugs based on humic substances for the correction of iron deficiency anemia, justification of the effectiveness and safety of their use" (State assignment of the Ministry of Health of the Russian Federation No. 056-00071-22-02, 2022-2024), leadership.
2. "Bionanomaterials and compositions with antimicrobial and wound-healing properties based on humic substances" (Grant of the Russian Science Foundation No. 20-65-47052 2020-2023), principal investigator.
3. "Pharmacological study of specific organic substances of Tomsk region peat" (RFBR Grant No. 18-43-700014, 2018-2021). 
   

1. Research of antianemic properties of new iron-containing substances based on natural humic substances.
2. Research of antioxidative activity of various natural substances.
3. Development of drug formulations for correction of iron deficiency states.
4. Research of wound-healing properties of new substances based on silver nanoparticles and natural humic substances.
5. Research of antibacterial properties of new substances based on silver nanoparticles and natural humic substances.
6. Development of drug formulations for treatment of purulent-inflammatory wound processes.
7. Development of standardization parameters for new iron-containing substances based on natural humic substances.
8. Chemical and pharmacological research of natural substances. 
   

• Pharmaceutical, chemical or pharmacological qualifications.
  English at an upper-intermediate or advanced level
  Experience in research projects
  Basic knowledge of statistical analysis in medical research 
  

1. Zykova M.V., Karpova M.R., Zhang Yu, Chubik M.V., Shunkova D.M., Azarkina L.A., Mihalyov D.A., Konstantinov A.I., Plotnikov E.V., Pestryakov A.N., Perminova I.V., Belousov M.V. The Influence of Silver-Containing Bionanomaterials Based on Humic Ligands on Biofilm Formation in Opportunistic Pathogens // Nanomaterials 2024, 14, 1453.
   
2. Zykova, M.V.; Bratishko, K.A.; Buyko, E.E.; Azarkina, L.A.; Ivanov, V.V.; Mihalyov, D.A.; Trofimova, E.S.; Danilets, M.G.; Ligacheva, A.A.; Konstantinov, A.I.; Ufandeev, A.A.; Rabtsevich, E.S.; Drygunova, L.A.; Zima, A.P.; Bashirov, S.R.; Udut, E.V.; Belousov, M.V. Coal-Derived Humic Substances: Insight into Chemical Structure Parameters and Biomedical Properties. Molecules. 2024, 29, 1530.
   
3. Zykova M.V., Volikov A.B., Buyko E.E., Bratishko K.A., Ivanov V.V., Konstantinov A.I., Logvinova L.A., Mihalyov D.A., Sobolev N.A., Zhirkova A.M., Maksimov S.V., Perminova I.V., Belousov M.V. Enhanced Antioxidant Activity and Reduced Cytotoxicity of Silver Nanoparticles Stabilized by Different Humic Materials // Polymers. 2023. 15. 3386.
   
4. Zykova M.V., Brazovskii K.S., Bratishko K.A., Buyko E.E., Logvinova L.A., Romanenko S.V., Konstantinov A.I., Krivoshchekov S.V., Perminova I.V., Belousov M.V. Quantitative Structure-Activity Relationship, Ontology-Based Model of the Antioxidant and Cell Protective Activity of Peat Humic Acids // Polymers, 2022, 14(16), 3293.
   
5. Zykova M.V., Veretennikova E.E., Logvinova L.A., Romanenko S.V., Bratishko K.A., Belousov M.V., Brazovsky K.S., Yusubov M.S., Lyapkov A.A., Danilets M.G., Trofimova E.S., Ligacheva A.A. New artificial network model to estimate biological activity of peat humic acids // Environmental Research. 2020. – Vol. 191. – P. 109999.
   
6. Volikov A.B., Mareev N.V., Konstantinov A.I., Molodykh A.A., Melnikova S.V., Bazhanova A.E., Gasanov M.E., Nikolaev E.N., Zherebker A.Ya., Volkov D.S., Zykova M.V., Perminova I.V. Directed Synthesis of Humic and Fulvic Derivatives with Enhanced Antioxidant Properties // Agronomy 2021, 11(10), 2047.
   
7. Klein O.I., Kulikova N.A., Konstantinov A.I., Zykova M.V., Perminova I.V. A systematic study of the antioxidant capacity of humic substances against peroxyl radicals: Relation to structure // Polymers, 2021, 13(19), 3262.