Siberian State Medical University

Intermediate (B1)

1. Grant of the Russian Foundation for Basic Research No. 08-04-00616 "Intra and extracellular proteolytic complexes of malignant neoplasms and their role in tumor metastasis", executive 2008-2010.
   
2. Federal target program "Scientific and scientific-pedagogical personnel of innovative Russia for 2009-2013", State contract No. P320, "Study of the role of components of cancer degradation in pathogenesis of malignant neoplasms", performer.
   
3. Federal target program "Scientific and scientific-pedagogical personnel of innovative Russia for 2009-2013", State Contract No. 02.740.11.0769; "Identification of protein markers for the diagnosis and prognosis of gastric cancer", Grant of the Russian Foundation for Basic Research No. 13-04-00169.13, contractor.
   
4. Grant of the Russian Foundation for Basic Research No. 13-04-00169.13 "Locomotor proteins and regulation of their expression in tumors of the female reproductive system", 2013-2015, performer.
   
5. Grant of the Russian Foundation for Basic Research 14-04-91150 GFEN_a Fundamental aspects of the participation of the system of insulin-like growth factors in the development of malignant neoplasms associated with metabolic syndrome 2014-2015, performer.
   
6. Grant of the President MD-3637.2015 "Development of molecular markers for predicting the course and effectiveness of targeted therapy for kidney cancer", head – MD Spirina L.V., 2015-2017 Head.
   
7. Grant of the Russian Foundation for Basic Research 17-04-00198 "Actin-binding proteins: the relationship with the type of cell migration and neoplastic transformation of the human epithelium", performer. 2017-2019.
   
8. RFBR grant 17-00-00186 "Molecular imaging of oncological pathologies of biological tissues in the terahertz region of the spectrum using time-resolved laser spectroscopy, big data analysis technologies and machine learning", COMFI, 2017-2019.
   
9. Grant from the Department of Biochemistry and Molecular Biology with the course of KLD "Molecular and biochemical mechanisms of the development of infectious and non-infectious somatic diseases based on the regulation of proteolysis and the formation of metabolic disorders", 2021, Head.
   
10. Grant from SibSMU for the creation of the laboratory of "Experimental Biochemistry and Biology", the project "The role of metabolic reprogramming in the development of chronic infectious and non-communicable human diseases, their correction under the influence of microRNAs and aluminum oxide and iron nanoparticles", 2022, Head.
    

1. The role of extracellular nucleic acids as predictors of the effectiveness of treatment of chronic non-communicable human diseases.
   
2. Development of a molecular approach to the study of the biological properties of nanoparticles of various origins.
   
3. Biochemical features of the action of cold plasma on epithelial and transformed cells.
   
4. Development of liquid biopsy approaches for the diagnosis of chronic non-communicable human diseases.
   
5. Clinical, epidemiological and molecular features of the development of melanomas.
   
6. Molecular genetic biomarkers of metabolic disorders, the possibility of their correction under the influence of microRNAs in vitro.
   
7. Analysis of metabolic changes in adipocytes under the influence of iron and aluminum nanoparticles in vitro.
   

• Biochemical and biological bases of nanoengineering of medical materials:
  
• "Metabolic disorders, their correction under the influence of microRNAs and nanoparticles of aluminum oxide and iron";
• "Molecular genetic features of the action of nanoparticles"
  
• Biochemical, molecular biological and immunological features of chronic non-communicable and infectious human diseases against the background of metabolic disorders: 
  
• "Blood monocytes in obesity in children"
• "The role of proteolytic systems in the development of complications against the background of a new coronavirus infection"
• Project: Identification of circulating tumor biomarkers based on NGS sequencing for the diagnosis and therapy of human diseases
• Project: The perspective of laboratory medicine
  

The planned research will be conducted under the guidance of the teachers of the Research Institute, there is an opportunity to learn how to work on unique equipment for gene sequencing, fragment analysis, the use of professional software products, as well as financial support for the research of a graduate student.

Knowledge of protein detection methods, the basics of PCR, the R and Python programming languages, basic statistical programs. It is mandatory to study bioinformatics and the basics of graphical representation of data in the background.

Web of Science, Scopus total number of publications - 54
RSCI number of publications - 50 

1. Knyazkova AI, Borisov AV, Spirina LV, Kistenev YV. Paraffin-embedded prostate cancer tissue grading using terahertz spectroscopy and machine learning. J Infrared Millim Terahertz Waves [Internet]. 2020;41(9):1089-104. DOI: 10.1007/s10762-020-00673-7 (IF=2.049)
2. Spirina LV, Yurmazov ZA, Gorbunov AK, Usynin EA, Lushnikova NA, Kovaleva IV. Molecular protein and expression profile in the primary tumors of clear cell renal carcinoma and metastases. Cells [Internet]. 2020;9(7) DOI: 10.3390/cells9071680 (IF=5.276)
3. Spirina LV, Chizhevskaya SY, Kondakova IV. Molecular profiling of follicular variant of papillary thyroid cancer. Bull Exp Biol Med [Internet]. 2020;169(1):85-8. DOI: 10.1007/s10517-020-04830-9 (IF=0.775)
4. Spirina LV, Avgustinovich AV, Afanas’ev SG, Chere-Misina OV, Volkov MY, Choynzonov EL, Gorbunov AK, Usynin EA. Molecular mechanism of resistance to chemotherapy in gastric cancers, the role of autophagy. Curr Drug Targets [Internet]. 2020;21(7):713-21. DOI: 10.2174/1389450120666191127113854 (IF=2.868)
5. Spirina L.; Avgustinovich A.; Afanas’ev S.; Volkov M.; Dobrodeev A.; Cheremisina O.; Kostromitsky D. PD-L1 Status in Gastric Cancers, Association with the Transcriptional, Growth Factors, AKT/mTOR Components Change, and Autophagy Initiation. Int. J. Mol. Sci. 2021; 22: 11176. https://doi.org/ 10.3390/ijms222011176 IF=6.0 (индексируется в WOS, Scopus, РИНЦ)

1. Spirina L.V., Kondakova I.V., Usynin E.A., Slonimskaya E.M., Yurmazov Z.A. A method for predicting the development of hematogenous metastases after combined treatment of kidney cancer. Patent for the invention of the Russian Federation No. 2528100 dated 07/16/2014
2. Spirina L.V., Kondakova I.V., Choinzonov E.L., Chizhevskaya S.Yu., Shishkin D.A. A method for predicting the development of lymphogenic metastases in squamous cell carcinomas of the head and neck after combined treatment. Patent for the invention of the Russian Federation No. 2527338 dated 08/27/2014
3. Spirina L.V., Usynin E.A., Kondakova I.V., Slonimskaya E.M. A method for predicting the outcome of muscle-invasive bladder cancer after combined treatment. Patent for the invention of the Russian Federation No. 2538632 dated 10.01.2015
4. Koval V.D., Kolomiets L.A., Spirina L.V., Chernyshova A.L., Kondakova I.V. A method for assessing the development of endometrial cancer in patients with endometrial hyperplastic processes. Patent for the invention of the Russian Federation No.2554505 dated 05/25/2015
5. Yurmazov Z.A., Slonimskaya E.M., Kondakova I.V., Usynin E.A., Spirina L.V. A method for predicting the outcome of the disease in patients with metastatic kidney cancer. Patent for the invention of the Russian Federation 2589286 dated 06/08/2016
6. Spirina L.V., Yurmazov Z.A., Slonimskaya E.M., Kondakova I.V., Usynin E.A. A method for predicting the effectiveness of everolimus therapy in patients with metastatic kidney cancer. Patent for the invention of the Russian Federation 2616533 dated 04/17/2017
7. Willert A.B., Kolomiets L.A., Yunusova N.V., Spirina L.V., Kondakova I.V., Cherdyntseva N.V., Gerdt L.V. A method for predicting the degree of probability of performing cytoreductive surgery in patients with disseminated ovarian cancer. Patent for the invention of the Russian Federation No. 2637399 dated 04.12.2017
8. Yunusova N.V., Willert A.B., Spirina L.V., Kolomiets L.A., Kondakova I.V. A method for predicting the effectiveness of neoadjuvant chemotherapy in patients with disseminated ovarian cancer. Patent for the invention of the Russian Federation No.2637410 dated 04.12.2017
9. Yurmazov Z.A., Spirina L.V., Slonimskaya E.M., Kondakova I.V., Usynin E.A. Patent for the invention of the Russian Federation 2650964 dated 04/18/2018 Method of personalized appointment of targeted therapy in patients with metastatic kidney cancer in preoperative mode
10. Spirina L.V., Chizhevskaya S.Yu., Kondakova I.V., Choinzonov E.L.Database of anamnestic, clinical, morphological and molecular parameters in patients with thyroid pathology Database No.2018620642 dated April 27, 2018
11. СSpirina L.V., Yurmazov Z.A., Lushnikova N.A., Usynin E.A., Slonimskaya E.M., Kondakova I.V. Database No.20196205247 Database of anamnestic, clinical, morphological and molecular parameters in patients with disseminated kidney cancer
12. Gorbunov A.K., Slonimskaya E.M., Spirina L.V., Usynin E.A., Kondakova I.V. Patent for the invention of the Russian Federation 2688181 dated 01/10/2019 METHOD FOR PREDICTING THE RESPONSE TIME TO ANDROGEN DEPRIVATION THERAPY IN PATIENTS WITH PROSTATE CANCER
13. Gorbunov A.K., Usynin E.A., Spirina L.V., Kondakova I.V. Certificate of state registration of data No.2019621535 dated 09/02/2019 Database of anamnestic, clinical, morphological, molecular parameters of patients with suspected prostate cancer and patients with stage II-IV prostate cancer
14. Kolomiets L.A., Ochirov M.O., Trukhaseva N.G., Chernyshova A.L., Churuksaeva O.N., Molchanov S.V., Willert A.B., Frolova I.G., Spirina L.V. Patent of the Russian Federation No.268770 dated 03/21/2018 Method of preoperative prediction of the probability of risk of lymphogenic metastasis in patients with stage T1 endometrial cancer
15. Certificate No.2020620978 dated 06/16/2020 "Database of anamnestic, clinical and morphological parameters of patients with bladder cancer" Spirina L.V., Usynin E.A. filing date 06/02/2020
16. Augustinovich A.V., Afanasyev S.G., Spirina L.V., Dobrodeev A.Yu., Samtsov E.N., Menshikov K.Yu., Frolova I.G. Patent No. 2756870 dated 05.10.2021 "Method of combined treatment of operable gastric cancer with positive PDL status"
17. Augustinovich A.V., Afanasyev S.G., Spirina L.V., Dobrodeev A.Yu., Volkov M.Yu., Bragina O.D., Chernov V.I. Patent No.2762319 dated 11/17/2021 Method of combined treatment of operable gastric cancer with HER2/neu overexpression
18. Patent No.2765845 dated 02/03/2022 "Method of combined treatment of locally advanced cardioesophageal cancer". Augustinovich A.V., Afanasyev S.G., Spirina L.V., Samtsov E.N., Volkov, Dobrodeev A.Yu., Frolova I.G., Startseva J.A.
19. Patent No.2776231 dated 07/14/2022 "METHOD FOR PREDICTING RELAPSES IN PATIENTS WITH CEREBRAL GLIOMAS". Spirina L.V., Ryabova A.I., Kondakova I.V., Medintseva E.Yu.
20. Patent No.2780942 dated 04.10.2022 "Method for predicting tumor invasion into a capsule in papillary thyroid cancer". Spirina L.V., Chizhevskaya S.Yu., Kondakova I.V., Kovaleva I.V., Kebekbayeva A.E.
21. Patent No.2756870 dated 05.10.2021 "Method of combined treatment of operable gastric cancer with positive PDL status"
22. Patent No.2762319 dated 11/17/2021 Method of combined treatment of operable gastric cancer with hyperexpression of HER2/neu Augustinovich A.V., Afanasyev S.G., Spirina L.V., Dobrodeev A.Yu., Volkov M.Yu., Bragina O.D., Chernov V.I.
23. Information on state registration No.2022620171 dated 01/19/2022 "Database of anamnestic, clinical, morphological, molecular parameters and indicators of single-photon emission computed tomography with radiopharmaceutical drug [99mTs]-Al2O3 for the diagnosis of "sentinel" lymph nodes in patients with skin melanoma". Nikulnikov K.V., Chizhevskaya S.Yu., Chernov V.I., Spirina L.V., Medvedeva A.A., Zelchan R.V.